Improvement of scopolamine-induced amnesia by cholecystokinin octapeptide and a new cholecystokinin heptapeptide analog in rats.
نویسندگان
چکیده
منابع مشابه
Cholecystokinin octapeptide inhibits carotid sinus baroreflex in anesthetized rats.
The purpose of this study was to determine the effect of cholecystokinin octapeptide (CCK-8) on carotid sinus baroreflex in 36 anesthetized male rats by isolated carotid sinus perfusion in vivo. The results obtained are as follows. (1) By perfusion with CCK-8 (0.1, 0.5, 1.0 micromol/L), the functional curve of baroreflex was shifted to the right and upward, with a decrease in peak slope (PS) (p...
متن کاملSynergistic effect of cholecystokinin octapeptide and angiotensin II in reversal of morphine induced analgesia in rats.
The aim of this paper is to study the synergistic anti-analgesic effect of angiotensin II (Ang II) plus cholecystokinin octapeptide (CCK-8). Our previous studies have shown that both CCK-8 and Ang II are potent anti-opioid substances. Intracerebroventricular (i.c.v.) injection of CCK-8 or Ang II dose-dependently antagonizes morphine-induced analgesia (MIA). In the present study, we observed the...
متن کاملCeruletide, an Analog of Cholecystokinin Octapeptide: New Perspectives on Its Efficacy
Ceruletide is the international nonproprietary name of caerulein, a decapeptide originally isolated from the skin of the Australian frog Hyla caerulea more than 30 years ago (2). Although caerulein does not exist in mammals, including humans, it closely resembles cholecystokinin octapeptide (CCK-8) in the C-terminal amino acid sequence (Fig. 1) and possesses a virtually identical spectrum of bi...
متن کاملCholecystokinin octapeptide immunization: effect on growth of barrows and gilts.
A study was conducted to validate the previously reported growth response to cholecystokinin octapeptide (CCK-8) immunization in barrows and was extended to include gilts. Group-penned barrows and gilts were used to represent conditions in the swine industry. Thirty-two animals, 19 barrows and 13 gilts, were randomly assigned by sex to four pens and two treatments. The control groups were immun...
متن کاملCholecystokinin and its COOH-terminal octapeptide in the pig brain.
Two components--one resembling intact cholecystokinin in size and charge and immunologic specificity, and the other resembling the COOH-terminal octapeptide of cholecystokinin--have been found in extracts of the pig cerebral cortex. The relative concentrations of the two peptides in the extracts were dependent on the extractant, boiling 0.1 M HCl being more effective than boiling water for the ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1991
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)38554-3